A multinational cohort study analysed the incidence of adverse events of special interest (AESI) following COVID-19 infection and compared them with historical rates in the general population. Primary care, electronic health records and insurance claims data were collected from multiple databases between January 2017 and May 2022. Sixteen pre-specified AESIs were identified, including acute myocardial infarction, anaphylaxis, stroke, thrombosis and myocarditis, among others.